4ajg: Difference between revisions

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[[Image:4ajg.jpg|left|200px]]


{{STRUCTURE_4ajg| PDB=4ajg | SCENE= }}
==Identification and structural characterization of PDE10 fragment inhibitors==
<StructureSection load='4ajg' size='340' side='right'caption='[[4ajg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [https://pdbe.org/4ajg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [https://www.ebi.ac.uk/pdbsum/4ajg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>


===Identification and structural characterization of PDE10 fragment inhibitors===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aharony, D.]]
[[Category: Large Structures]]
[[Category: Akerud, T.]]
[[Category: Aharony D]]
[[Category: Albert, J S.]]
[[Category: Akerud T]]
[[Category: Back, E.]]
[[Category: Albert JS]]
[[Category: Geschwindner, S.]]
[[Category: Back E]]
[[Category: Hillertz, P.]]
[[Category: Geschwindner S]]
[[Category: Horsefeld, R.]]
[[Category: Hillertz P]]
[[Category: Johansson, P.]]
[[Category: Horsefeld R]]
[[Category: Scott, C.]]
[[Category: Johansson P]]
[[Category: Spadola, L.]]
[[Category: Scott C]]
[[Category: Spear, N.]]
[[Category: Spadola L]]
[[Category: Tian, G.]]
[[Category: Spear N]]
[[Category: Tigerstrom, A.]]
[[Category: Tian G]]
[[Category: Hydrolase]]
[[Category: Tigerstrom A]]
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