2laq: Difference between revisions

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[[Image:2laq.png|left|200px]]


{{STRUCTURE_2laq| PDB=2laq |  SCENE= }}
==Solution structure of the Sex Peptide from Drosophila melanogaster==
<StructureSection load='2laq' size='340' side='right'caption='[[2laq]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2laq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2laq OCA], [https://pdbe.org/2laq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2laq RCSB], [https://www.ebi.ac.uk/pdbsum/2laq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2laq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A70A_DROME A70A_DROME] Represses female sexual receptivity and stimulates oviposition.<ref>PMID:3135120</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The insect sex peptide (SP) elicits a variety of biological responses upon transfer to the mated female. SP contains 36 amino acids, including a tryptophan-rich N-terminal region, a central region containing five hydroxyproline (Hyp) residues, and a C-terminal region enclosed by a disulfide bridge. The solution structure of SP, studied here using NMR spectroscopy, includes a motif WPWN that adopts a type I beta-turn in the N-terminal Trp-rich region. This turn region is connected to the central Hyp-rich region, which adopts extended and/or PPII-like conformations. The C-terminal disulfide-bonded loop populates helical turns or nascent helical structure. Overall, the results reveal a rather flexible peptide that lacks a compact folded structure in solution.


===Solution structure of the Sex Peptide from Drosophila melanogaster===
NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster.,Moehle K, Freund A, Kubli E, Robinson JA FEBS Lett. 2011 Apr 20;585(8):1197-202. Epub 2011 Mar 23. PMID:21439282<ref>PMID:21439282</ref>


{{ABSTRACT_PUBMED_21439282}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2laq" style="background-color:#fffaf0;"></div>
[[2laq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAQ OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:021439282</ref><references group="xtra"/>
</StructureSection>
[[Category: Freund, A.]]
[[Category: Drosophila melanogaster]]
[[Category: Moehle, K.]]
[[Category: Large Structures]]
[[Category: Robinson, J A.]]
[[Category: Freund A]]
[[Category: Hydroxiproline rich]]
[[Category: Moehle K]]
[[Category: Signaling protein]]
[[Category: Robinson JA]]

Latest revision as of 08:54, 14 June 2023

Solution structure of the Sex Peptide from Drosophila melanogaster

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