Cholesterol esterase: Difference between revisions

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{{STRUCTURE_1llf|  PDB=1llf | SIZE=400| SCENE= |right|CAPTION=Cholesterol esterase dimer complex with bile acid [[1llf]] }}
<StructureSection load='1llf' size='350' side='right' caption='Glycosylated cholesterol esterase dimer complex with bile acid (PDB entry [[1llf]])' scene='52/525136/Cv/1'>
== Function ==


'''Cholesterol esterase''' (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides. Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.
'''Cholesterol esterase''' (ChoE) also named '''bile-salt activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref>


==3D structures of cholesterol esterase==
== Disease ==
 
Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Structural highlights ==


[[1akn]] – bChoE – bovine<br />
ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref>
[[2bce]] – bChoE (mutant)<br />
[[1jmy]] – hChoE - human<br />
[[1f6w]] – hChoE catalytic domain (mutant)


==Cholesterol esterase complex with bile acids==
==3D structures of cholesterol esterase==
[[Cholesterol esterase 3D structures]]


[[1cle]] – CcChoE + cholesteryl linoleate – ''Candida cylindracea''<br />
</StructureSection>
[[1llf]] – CcChoE + tricosanoic acid<br />
[[1aql]] – bChoE + taurocholate


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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