Fibrin: Difference between revisions

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[[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]]
<StructureSection load='1n73' size='350' side='right' scene='41/417472/Cv/3' caption='Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry [[1n73]])'>
{{STRUCTURE_1n73|  PDB=1n73  | SIZE=400| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin α1 subunit (red, yellow), β subunit (Green, blue), γ subunit (orange, magenta) from ''Petromyzon marinus'', [[1n73]] }}


== Function ==


[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob.  [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin.  Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa)<ref>PMID:12501189</ref>.


== Disease ==


Overexpression of FIa can cause thrombosis.


== Structural highlights ==


<scene name='41/417472/Cv/6'>Ca coordination site in β subunit</scene>.


 
<scene name='41/417472/Cv/7'>Ca coordination site in γ subunit</scene> (PDB entry [[1n73]]).  
 
</StructureSection>
 
 
 
 
[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob.  [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin.  Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, ''i.e.'' the crystal structure of Fibrin from ''Petromyzon marinus'' ([[1n73]]).
 
{{TOC limit|limit=2}}
 
== 3D Structures of Fibrin ==
== 3D Structures of Fibrin ==


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[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[1n8e]] - hFIa α, β, γ chains <br />
[[1n8e]] - hFIa α, β, γ chains <br />
[[2a45]] - hFIa α, β, γ chains + thrombin<br />
[[1fzc]] – hDDFIa+peptide<br />
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
[[1fzc]] – hDDFIa+peptide<br />
 
== References ==
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]
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