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{{STRUCTURE_1iga|  PDB=1iga  |  SCENE=  }}
===MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING===
{{ABSTRACT_PUBMED_10064707}}


==About this Structure==
==MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING==
[[1iga]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IGA OCA].  
<StructureSection load='1iga' size='340' side='right'caption='[[1iga]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1iga]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IGA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iga OCA], [https://pdbe.org/1iga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iga RCSB], [https://www.ebi.ac.uk/pdbsum/1iga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iga ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
== Function ==
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/1iga_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iga ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[IgA|IgA]]
*[[Antibody 3D structures|Antibody 3D structures]]
 
*[[3D structures of human antibody|3D structures of human antibody]]
==Reference==
__TOC__
<ref group="xtra">PMID:010064707</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boehm, M K.]]
[[Category: Large Structures]]
[[Category: Kerr, M A.]]
[[Category: Boehm MK]]
[[Category: Perkins, S J.]]
[[Category: Kerr MA]]
[[Category: Woof, J M.]]
[[Category: Perkins SJ]]
[[Category: Iga1]]
[[Category: Woof JM]]
[[Category: Immunoglobulin]]
Retrieved from "https://proteopedia.org/1iga"