4j3e: Difference between revisions

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'''Unreleased structure'''


The entry 4j3e is ON HOLD  until Paper Publication
==The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a==
<StructureSection load='4j3e' size='340' side='right'caption='[[4j3e]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4j3e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J3E FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j3e OCA], [https://pdbe.org/4j3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j3e RCSB], [https://www.ebi.ac.uk/pdbsum/4j3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j3e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).


Authors: Graves, B.J., Lukacs, C.M., Kammlott, R.U., Crowther, R.
==See Also==
 
*[[MDM2 3D structures|MDM2 3D structures]]
Description: The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Crowther R]]
[[Category: Graves BJ]]
[[Category: Kammlott RU]]
[[Category: Lukacs CM]]
Retrieved from "https://proteopedia.org/4j3e"