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{{STRUCTURE_3ik8|  PDB=3ik8  |  SCENE=  }}
===Structure-Based Design of Novel PIN1 Inhibitors (I)===
{{ABSTRACT_PUBMED_19729306}}


==About this Structure==
==Structure-Based Design of Novel PIN1 Inhibitors (I)==
[[3ik8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK8 OCA].  
<StructureSection load='3ik8' size='340' side='right'caption='[[3ik8]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ik8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik8 OCA], [https://pdbe.org/3ik8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ik8 ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
<ref group="xtra">PMID:019729306</ref><references group="xtra"/>
*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Ferre, R A.]]
[[Category: Ferre RA]]
[[Category: Greasley, S.]]
[[Category: Greasley S]]
[[Category: Matthews, D.]]
[[Category: Matthews D]]
[[Category: Parge, H.]]
[[Category: Parge H]]
[[Category: Cell cycle]]
[[Category: Isomerase]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Ppiase]]
[[Category: Rotamase]]
[[Category: Sbdd]]
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