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{{STRUCTURE_3iip|  PDB=3iip  |  SCENE=  }}
===Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series===
{{ABSTRACT_PUBMED_20036254}}


==About this Structure==
==Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series==
[[3iip]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IIP OCA].  
<StructureSection load='3iip' size='340' side='right'caption='[[3iip]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3iip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IIP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iip OCA], [https://pdbe.org/3iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iip RCSB], [https://www.ebi.ac.uk/pdbsum/3iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iip ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/3iip_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iip ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Directed evolution|Directed evolution]]
*[[Kemp eliminase|Kemp eliminase]]
*[[Kemp eliminase|Kemp eliminase]]
*[[Kemp elimination catalyst|Kemp elimination catalyst]]
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:020036254</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Dym, O.]]
[[Category: Large Structures]]
[[Category: Khersonsky, O.]]
[[Category: Dym O]]
[[Category: Tawfik, D S.]]
[[Category: Khersonsky O]]
[[Category: Beta barrel]]
[[Category: Tawfik DS]]
[[Category: Lyase]]
Retrieved from "https://proteopedia.org/3iip"