4bf4: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4bf4 is ~~ON HOLD~~

==PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group==

== Structural highlights ==

<table><tr><td colspan='2'>[[4bf4]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4BF4 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=17Q:1.7.6+5-CYCLODODECYLOXY-N,N-DIMETHYL-PENTAN-1-AMINE'>17Q</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4bf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf4 OCA], [https://pdbe.org/4bf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bf4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf4 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref>

~~Authors~~: ~~Podust, L.M.~~

==See Also==

*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]]

~~Description~~: ~~PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group~~

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Streptomyces venezuelae]]

[[Category: Podust LM]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4bf4 is ON HOLD
+==PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group==
+<StructureSection load='4bf4' size='340' side='right'caption='[[4bf4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4bf4]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BF4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=17Q:1.7.6+5-CYCLODODECYLOXY-N,N-DIMETHYL-PENTAN-1-AMINE'>17Q</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bf4 OCA], [https://pdbe.org/4bf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bf4 RCSB], [https://www.ebi.ac.uk/pdbsum/4bf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bf4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref>
-Authors: Podust, L.M.
+==See Also==
+*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]]
-Description: PikC D50N mutant in complex with the engineered cycloalkane substrate mimic bearing a termianl N,N-dimethylamino group
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Streptomyces venezuelae]]
+[[Category: Podust LM]]