3tkb: Difference between revisions
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== | ==crystal structure of human uracil-DNA glycosylase D183G/K302R mutant== | ||
[[http://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN | <StructureSection load='3tkb' size='340' side='right'caption='[[3tkb]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3tkb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkb OCA], [https://pdbe.org/3tkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tkb RCSB], [https://www.ebi.ac.uk/pdbsum/3tkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tkb ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN] Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5) [MIM:[https://omim.org/entry/608106 608106]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:12958596</ref> <ref>PMID:15967827</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UNG_HUMAN UNG_HUMAN] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | |||
== | ==See Also== | ||
[[ | *[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Assefa | [[Category: Assefa NG]] | ||
[[Category: Moe | [[Category: Moe E]] | ||
[[Category: Niiranen | [[Category: Niiranen L]] | ||
[[Category: Smalas | [[Category: Smalas AO]] | ||
[[Category: Willassen | [[Category: Willassen NP]] | ||
Latest revision as of 13:31, 14 March 2024
crystal structure of human uracil-DNA glycosylase D183G/K302R mutant
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