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{{STRUCTURE_2l1x|  PDB=2l1x  |  SCENE=  }}
===The Solution Structure Of Human Parathyroid Hormone-Related Protein===
{{ABSTRACT_PUBMED_022517776}}


==Disease==
==The Solution Structure Of Human Parathyroid Hormone-Related Protein==
[[http://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN]] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[http://omim.org/entry/146200 146200]]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref><ref>PMID:10523031</ref><ref>PMID:18056632</ref>  
<StructureSection load='2l1x' size='340' side='right'caption='[[2l1x]]' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2l1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1X FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN]] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1x OCA], [https://pdbe.org/2l1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1x RCSB], [https://www.ebi.ac.uk/pdbsum/2l1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1x ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2l1x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1X OCA].
== Disease ==
 
[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[https://omim.org/entry/146200 146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref> <ref>PMID:10523031</ref> <ref>PMID:18056632</ref>  
==Reference==
== Function ==
<references group="xtra"/><references/>
[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lin, D.]]
[[Category: Large Structures]]
[[Category: Lin, K.]]
[[Category: Lin D]]
[[Category: Liu, J.]]
[[Category: Lin K]]
[[Category: You, Q.]]
[[Category: Liu J]]
[[Category: Hormone]]
[[Category: You Q]]
[[Category: Pthrp]]
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