1qtt: Difference between revisions
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== | ==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1== | ||
[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN | <StructureSection load='1qtt' size='340' side='right'caption='[[1qtt]]' scene=''> | ||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[1qtt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTT FirstGlance]. <br> | ||
[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtt OCA], [https://pdbe.org/1qtt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtt RCSB], [https://www.ebi.ac.uk/pdbsum/1qtt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtt ProSAT]</span></td></tr> | |||
== | </table> | ||
[[ | == Disease == | ||
[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia. | |||
== Function == | |||
< | [https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref> | ||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtt_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtt ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Guignard | [[Category: Large Structures]] | ||
[[Category: Lhoste | [[Category: Guignard L]] | ||
[[Category: Mispelter | [[Category: Lhoste J-M]] | ||
[[Category: Padilla | [[Category: Mispelter J]] | ||
[[Category: Roumestand | [[Category: Padilla A]] | ||
[[Category: Stern | [[Category: Roumestand C]] | ||
[[Category: Yang | [[Category: Stern M-H]] | ||
[[Category: Yang Y-S]] | |||
Latest revision as of 06:07, 17 April 2024
SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1
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