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{{STRUCTURE_2l85|  PDB=2l85  |  SCENE=  }}
===Solution NMR structures of CBP bromodomain with small molecule of HBS===
{{ABSTRACT_PUBMED_21513889}}


==Disease==
==Solution NMR structures of CBP bromodomain with small molecule of HBS==
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref><ref>PMID:12114483</ref><ref>PMID:12566391</ref><ref>PMID:15706485</ref>  
<StructureSection load='2l85' size='340' side='right'caption='[[2l85]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2l85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L85 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L85:4-[(E)-(4-HYDROXYPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>L85</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l85 OCA], [https://pdbe.org/2l85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l85 RCSB], [https://www.ebi.ac.uk/pdbsum/2l85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l85 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
== Function ==
[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>  


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref><ref>PMID:11154691</ref><ref>PMID:12738767</ref><ref>PMID:12929931</ref>
*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[2l85]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L85 OCA].
__TOC__
 
</StructureSection>
==Reference==
<ref group="xtra">PMID:021513889</ref><references group="xtra"/><references/>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Borah, J C.]]
[[Category: Large Structures]]
[[Category: Gerona-Navarro, G.]]
[[Category: Borah JC]]
[[Category: Hajjar, R J.]]
[[Category: Gerona-Navarro G]]
[[Category: Karakikes, I.]]
[[Category: Hajjar RJ]]
[[Category: Morohashi, K.]]
[[Category: Karakikes I]]
[[Category: Moshkina, N.]]
[[Category: Morohashi K]]
[[Category: Mujtaba, S.]]
[[Category: Moshkina N]]
[[Category: Muller, M.]]
[[Category: Mujtaba S]]
[[Category: Patel, J.]]
[[Category: Muller M]]
[[Category: Zeng, L.]]
[[Category: Patel J]]
[[Category: Zhang, W.]]
[[Category: Zeng L]]
[[Category: Zhou, M.]]
[[Category: Zhang W]]
[[Category: P53]]
[[Category: Zhou M]]
[[Category: Transferase]]
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