2lce: Difference between revisions
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== | ==Chemical shift assignment of Hr4436B from Homo Sapiens, Northeast Structural Genomics Consortium== | ||
[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN | <StructureSection load='2lce' size='340' side='right'caption='[[2lce]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2lce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LCE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lce OCA], [https://pdbe.org/2lce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lce RCSB], [https://www.ebi.ac.uk/pdbsum/2lce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lce ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | |||
== | ==See Also== | ||
[[ | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
<references | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Acton | [[Category: Large Structures]] | ||
[[Category: Ciccosanti | [[Category: Acton TB]] | ||
[[Category: Everett | [[Category: Ciccosanti C]] | ||
[[Category: Janjua | [[Category: Everett JK]] | ||
[[Category: Lee | [[Category: Janjua H]] | ||
[[Category: Montelione | [[Category: Lee H]] | ||
[[Category: Montelione GT]] | |||
[[Category: Prestegard | [[Category: Prestegard JH]] | ||
[[Category: Shastry | [[Category: Shastry R]] | ||
[[Category: Xiao | [[Category: Xiao R]] | ||
Latest revision as of 05:41, 15 May 2024
Chemical shift assignment of Hr4436B from Homo Sapiens, Northeast Structural Genomics Consortium
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