2cp9: Difference between revisions

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[[Image:2cp9.gif|left|200px]]<br /><applet load="2cp9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2cp9" />
'''Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts'''<br />


==Disease==
==Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts==
Known disease associated with this structure: Combined oxidative phosphorylation deficiency 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604723 604723]]
<StructureSection load='2cp9' size='340' side='right'caption='[[2cp9]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CP9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cp9 OCA], [https://pdbe.org/2cp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cp9 RCSB], [https://www.ebi.ac.uk/pdbsum/2cp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cp9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cp9 TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN] Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3) [MIM:[https://omim.org/entry/610505 610505]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.<ref>PMID:17033963</ref>
== Function ==
[https://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN] Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).[HAMAP-Rule:MF_03135]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cp9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cp9 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2CP9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP9 OCA].
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hirota, H.]]
[[Category: Hirota H]]
[[Category: Izumi, K.]]
[[Category: Izumi K]]
[[Category: Ohashi, W.]]
[[Category: Ohashi W]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: human]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: uba]]
 
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Retrieved from "https://proteopedia.org/2cp9"