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{{STRUCTURE_3tdl|  PDB=3tdl  |  SCENE=  }}
===Structure of human serum albumin in complex with DAUDA===
{{ABSTRACT_PUBMED_21997768}}


==Disease==
==Structure of human serum albumin in complex with DAUDA==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>  
<StructureSection load='3tdl' size='340' side='right'caption='[[3tdl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TDL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=11D:11-({[5-(DIMETHYLAMINO)NAPHTHALEN-1-YL]SULFONYL}AMINO)UNDECANOIC+ACID'>11D</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tdl OCA], [https://pdbe.org/3tdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tdl RCSB], [https://www.ebi.ac.uk/pdbsum/3tdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tdl ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>  
== Function ==
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
11-(Dansylamino) undecanoic acid (DAUDA) is a dansyl-type fluorophore and has widely used as a probe to determine the binding site for human serum albumin (HSA). Here, we reported that structure of HSA-Myristate-DAUDA ternary complex and identified clearly the presence of two DAUDA molecules at fatty acid (FA) binding site 6 and 7 of HSA, thus showing these two sites are weak FA binding sites. This result also show that DAUDA is an appropriate probe for FA site 6 and 7 on HSA as previous studied, but not a good probe of FA binding site 1 that is likely bilirubin binding site on HSA.


==Function==
A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin.,Wang Y, Luo Z, Shi X, Wang H, Nie L, Huang M Protein Sci. 2011 Dec;20(12):2095-101. doi: 10.1002/pro.749. Epub 2011 Nov 9. PMID:21997768<ref>PMID:21997768</ref>
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>  


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[3tdl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDL OCA].
</div>
<div class="pdbe-citations 3tdl" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Albumin|Albumin]]
*[[Albumin 3D structures|Albumin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021997768</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Luo, Z.]]
[[Category: Large Structures]]
[[Category: Nie, L.]]
[[Category: Luo Z]]
[[Category: Shi, X.]]
[[Category: Nie L]]
[[Category: Wang, H.]]
[[Category: Shi X]]
[[Category: Wang, Y.]]
[[Category: Wang H]]
[[Category: Dauda]]
[[Category: Wang Y]]
[[Category: Fluorescent fatty acid analogue]]
[[Category: Human serum albumin]]
[[Category: Myristate]]
[[Category: Protein binding]]
[[Category: Protein-drug complex]]
[[Category: Transport protein]]
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