3ioz: Difference between revisions

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{{STRUCTURE_3ioz|  PDB=3ioz  |  SCENE=  }}
===SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93)===
{{ABSTRACT_PUBMED_20124696}}


==Disease==
==SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93)==
[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[http://omim.org/entry/610163 610163]]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref>  
<StructureSection load='3ioz' size='340' side='right'caption='[[3ioz]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ioz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_cpz Simian immunodeficiency virus - cpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.699&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ioz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ioz OCA], [https://pdbe.org/3ioz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ioz RCSB], [https://www.ebi.ac.uk/pdbsum/3ioz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ioz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5QGG3_SIV Q5QGG3_SIV]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/3ioz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ioz ConSurf].
<div style="clear:both"></div>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
*[[CD3 3D structures|CD3 3D structures]]
 
*[[Protein Nef 3D structures|Protein Nef 3D structures]]
==About this Structure==
__TOC__
[[3ioz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOZ OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:020124696</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Simian immunodeficiency virus]]
[[Category: Large Structures]]
[[Category: Kim, W M.]]
[[Category: Simian immunodeficiency virus - cpz]]
[[Category: Sigalov, A B.]]
[[Category: Kim WM]]
[[Category: Stern, L J.]]
[[Category: Sigalov AB]]
[[Category: Cell membrane]]
[[Category: Stern LJ]]
[[Category: Disulfide bond]]
[[Category: Host-virus interaction]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Myristate]]
[[Category: Phosphoprotein]]
[[Category: Protein-protein complex]]
[[Category: Receptor]]
[[Category: Transmembrane]]
[[Category: Viral immunoevasion]]
[[Category: Viral protein-antiviral protein complex]]
[[Category: Viral protein-signaling protein complex]]
[[Category: Virulence]]

Latest revision as of 10:06, 21 February 2024

SIVmac239 Nef in complex with a TCR zeta polypeptide DP1 (L51-D93)

3ioz, resolution 3.70Å

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