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{{STRUCTURE_1nwr|  PDB=1nwr  |  SCENE=  }}
===Crystal structure of human cartilage gp39 (HC-gp39)===
{{ABSTRACT_PUBMED_12851408}}


==Disease==
==Crystal structure of human cartilage gp39 (HC-gp39)==
[[http://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN]] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[http://omim.org/entry/611960 611960]]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.  
<StructureSection load='1nwr' size='340' side='right'caption='[[1nwr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[1nwr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWR FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwr OCA], [https://pdbe.org/1nwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwr RCSB], [https://www.ebi.ac.uk/pdbsum/1nwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwr ProSAT]</span></td></tr>
[[1nwr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWR OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
== Function ==
[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwr ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Chitinase-3-like protein 1|Chitinase-3-like protein 1]]
*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012851408</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bos, E.]]
[[Category: Large Structures]]
[[Category: Dijkstra, B W.]]
[[Category: Bos E]]
[[Category: Fusetti, F.]]
[[Category: Dijkstra BW]]
[[Category: Kalk, K H.]]
[[Category: Fusetti F]]
[[Category: Pijning, T.]]
[[Category: Kalk KH]]
[[Category: Chitin]]
[[Category: Pijning T]]
[[Category: Chitinase-like protein]]
[[Category: N-acetylglucosamine]]
[[Category: Rheumatoid arthritis]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/1nwr"