2d8u: Difference between revisions

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[[Image:2d8u.gif|left|200px]]<br /><applet load="2d8u" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2d8u" />
'''Solution structure of the B-box domain of the human tripartite motif-containing 63 protein'''<br />


==Disease==
==Solution structure of the B-box domain of the human tripartite motif-containing 63 protein==
Known diseases associated with this structure: Gastric cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147575 147575]], Macrocytic anemia, refractory, of 5q- syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147575 147575]], Myelodysplastic syndrome, preleukemic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147575 147575]], Myelogenous leukemia, acute OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147575 147575]], Nonsmall cell lung cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147575 147575]]
<StructureSection load='2d8u' size='340' side='right'caption='[[2d8u]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2d8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8u OCA], [https://pdbe.org/2d8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8u RCSB], [https://www.ebi.ac.uk/pdbsum/2d8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8u ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8u TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/2d8u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d8u ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2D8U is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8U OCA].
*[[Mur ligase|Mur ligase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Miyamoto, K.]]
[[Category: Miyamoto K]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: iris ring finger protein]]
[[Category: murf1]]
[[Category: muscle-specific ring finger protein 1]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: ring finger protein 28]]
[[Category: rsgi]]
[[Category: striated muscle ring zinc finger protein]]
[[Category: structural genomics]]
[[Category: trim63]]
[[Category: tripartite motif-containing 63]]
[[Category: zf-b_box]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:56:15 2008''
Retrieved from "https://proteopedia.org/2d8u"