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{{STRUCTURE_3fb2|  PDB=3fb2  |  SCENE=  }}
===Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.===


==Disease==
==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.==
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:[http://omim.org/entry/613477 613477]]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.<ref>PMID:20493457</ref>  
<StructureSection load='3fb2' size='340' side='right'caption='[[3fb2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB2 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [https://pdbe.org/3fb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb2 ProSAT], [https://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr>
[[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN] West syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.


==See Also==
==See Also==
*[[Spectrin|Spectrin]]
*[[Spectrin 3D structures|Spectrin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Acton, T B.]]
[[Category: Large Structures]]
[[Category: Ciccosanti, C.]]
[[Category: Acton TB]]
[[Category: Foote, E L.]]
[[Category: Ciccosanti C]]
[[Category: Hunt, J F.]]
[[Category: Foote EL]]
[[Category: Janjua, H.]]
[[Category: Hunt JF]]
[[Category: Montelione, G T.]]
[[Category: Janjua H]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: Seetharaman, J.]]
[[Category: Seetharaman J]]
[[Category: Shastry, R.]]
[[Category: Shastry R]]
[[Category: Su, M.]]
[[Category: Su M]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Vorobiev, S M.]]
[[Category: Vorobiev SM]]
[[Category: Xiao, R.]]
[[Category: Xiao R]]
[[Category: Actin capping]]
[[Category: Actin-binding]]
[[Category: Brain spectrin]]
[[Category: Calmodulin-binding]]
[[Category: Cytoskeleton]]
[[Category: Fordrin alpha chain]]
[[Category: Hr5563a]]
[[Category: Nesg]]
[[Category: Non-erythroid alpha chain alpha-ii spectrin]]
[[Category: Northeast structural genomics consortium]]
[[Category: Phosphoprotein]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Sh3 domain]]
[[Category: Spectrin alpha chain]]
[[Category: Spta2_human]]
[[Category: Sptan1]]
[[Category: Structural genomic]]
[[Category: Structural protein]]

Latest revision as of 09:32, 6 December 2023

Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.

3fb2, resolution 2.30Å

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