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{{STRUCTURE_2kcx|  PDB=2kcx  |  SCENE=  }}
===Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.===


==Disease==
==Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.==
[[http://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.  
<StructureSection load='2kcx' size='340' side='right'caption='[[2kcx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KCX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kcx OCA], [https://pdbe.org/2kcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kcx RCSB], [https://www.ebi.ac.uk/pdbsum/2kcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kcx ProSAT], [https://www.topsan.org/Proteins/NESGC/2kcx TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN] Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.
== Function ==
[https://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN] Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.<ref>PMID:11948405</ref> <ref>PMID:15451575</ref> <ref>PMID:15574124</ref> <ref>PMID:16336961</ref> <ref>PMID:17868029</ref> <ref>PMID:17878677</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/2kcx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kcx ConSurf].
<div style="clear:both"></div>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/FSTL3_HUMAN FSTL3_HUMAN]] Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.<ref>PMID:11948405</ref><ref>PMID:15451575</ref><ref>PMID:15574124</ref><ref>PMID:16336961</ref><ref>PMID:17868029</ref><ref>PMID:17878677</ref>
*[[Follistatin|Follistatin]]
 
== References ==
==About this Structure==
<references/>
[[2kcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCX OCA].
__TOC__
 
</StructureSection>
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Anderson, S.]]
[[Category: Large Structures]]
[[Category: Chiang, Y.]]
[[Category: Anderson S]]
[[Category: Montelione, G T.]]
[[Category: Chiang Y]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: Rossi, P.]]
[[Category: Rossi P]]
[[Category: Follistatin]]
[[Category: Glycoprotein]]
[[Category: Kazal-1]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Nucleotide-binding protein]]
[[Category: Nucleus]]
[[Category: Protein structure initiative]]
[[Category: Proto-oncogene]]
[[Category: Psi-2]]
[[Category: Secreted]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/2kcx"