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{{STRUCTURE_2dnf|  PDB=2dnf  |  SCENE=  }}
===Solution structure of RSGI RUH-062, a DCX domain from human===


==Disease==
==Solution structure of RSGI RUH-062, a DCX domain from human==
[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[http://omim.org/entry/600202 600202]]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>  
<StructureSection load='2dnf' size='340' side='right'caption='[[2dnf]]' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2dnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNF FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN]] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnf OCA], [https://pdbe.org/2dnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnf RCSB], [https://www.ebi.ac.uk/pdbsum/2dnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnf ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnf TOPSAN]</span></td></tr>
==About this Structure==
</table>
[[2dnf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNF OCA].  
== Disease ==
 
[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN] Defects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:[https://omim.org/entry/600202 600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.<ref>PMID:16278297</ref>  
==Reference==
== Function ==
<references group="xtra"/><references/>
[https://www.uniprot.org/uniprot/DCDC2_HUMAN DCDC2_HUMAN] May be involved in neuronal migration during development of the cerebral neocortex (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dnf ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hayashi, F.]]
[[Category: Large Structures]]
[[Category: Hirota, H.]]
[[Category: Hayashi F]]
[[Category: Nagashima, T.]]
[[Category: Hirota H]]
[[Category: Ohashi, W.]]
[[Category: Nagashima T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Ohashi W]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Doublecortin]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Protein binding]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2dnf"