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{{STRUCTURE_3qxc|  PDB=3qxc  |  SCENE=  }}
===Crystal structure of dethiobiotin synthetase (BioD) from Helicobacter pylori complexed with ATP===
{{ABSTRACT_PUBMED_22284390}}


==Function==
==Crystal structure of dethiobiotin synthetase (BioD) from Helicobacter pylori complexed with ATP==
[[http://www.uniprot.org/uniprot/BIOD_HELPY BIOD_HELPY]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity).[HAMAP-Rule:MF_00336]  
<StructureSection load='3qxc' size='340' side='right'caption='[[3qxc]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3qxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QXC FirstGlance]. <br>
[[3qxc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QXC OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qxc OCA], [https://pdbe.org/3qxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qxc RCSB], [https://www.ebi.ac.uk/pdbsum/3qxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qxc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIOD_HELPY BIOD_HELPY] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity).[HAMAP-Rule:MF_00336]


==See Also==
==See Also==
*[[Dethiobiotin synthetase|Dethiobiotin synthetase]]
*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022284390</ref><references group="xtra"/><references/>
[[Category: Dethiobiotin synthase]]
[[Category: Helicobacter pylori 26695]]
[[Category: Helicobacter pylori 26695]]
[[Category: Chruszcz, M.]]
[[Category: Large Structures]]
[[Category: Joachimiak, A.]]
[[Category: Chruszcz M]]
[[Category: Klimecka, M M.]]
[[Category: Joachimiak A]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Klimecka MM]]
[[Category: Minor, W.]]
[[Category: Minor W]]
[[Category: Murzyn, K.]]
[[Category: Murzyn K]]
[[Category: Porebski, P J.]]
[[Category: Porebski PJ]]
[[Category: Atp binding]]
[[Category: Dethiobiotin synthetase]]
[[Category: Dtb]]
[[Category: Ligase]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]

Latest revision as of 12:02, 14 March 2024

Crystal structure of dethiobiotin synthetase (BioD) from Helicobacter pylori complexed with ATP

3qxc, resolution 1.34Å

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