3vqf: Difference between revisions

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~~{{STRUCTURE_3vqf| PDB=3vqf | SCENE= }}~~

~~===Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein===~~

==~~About this~~ Structure==

==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==

[[3vqf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA].

== Structural highlights ==

<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQF FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.199Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [https://pdbe.org/3vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [https://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

==See Also==

*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Akiyoshi, Y.]]

[[Category: Akiyoshi Y]]

[[Category: Furuse, M.]]

[[Category: Furuse M]]

[[Category: Goda, N.]]

[[Category: Goda N]]

[[Category: Hamada, D.]]

[[Category: Hamada D]]

[[Category: Hiroaki, H.]]

[[Category: Hiroaki H]]

[[Category: Nakagawa, A.]]

[[Category: Nakagawa A]]

[[Category: Narita, H.]]

[[Category: Narita H]]

[[Category: Suzuki, M.]]

[[Category: Suzuki M]]

[[Category: Tenno, T~~.]]~~

[[Category: Tenno T]]

~~[[Category: Claudin c-terminus]]~~

~~[[Category: Pdz domain]]~~

~~[[Category: Peptide binding protein~~]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3vqf|  PDB=3vqf  |  SCENE=  }}
-===Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein===
-==About this Structure==
+==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==
-[[3vqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA].
+<StructureSection load='3vqf' size='340' side='right'caption='[[3vqf]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.199&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [https://pdbe.org/3vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [https://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.  Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
+==See Also==
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Akiyoshi, Y.]]
+[[Category: Akiyoshi Y]]
-[[Category: Furuse, M.]]
+[[Category: Furuse M]]
-[[Category: Goda, N.]]
+[[Category: Goda N]]
-[[Category: Hamada, D.]]
+[[Category: Hamada D]]
-[[Category: Hiroaki, H.]]
+[[Category: Hiroaki H]]
-[[Category: Nakagawa, A.]]
+[[Category: Nakagawa A]]
-[[Category: Narita, H.]]
+[[Category: Narita H]]
-[[Category: Suzuki, M.]]
+[[Category: Suzuki M]]
-[[Category: Tenno, T.]]
+[[Category: Tenno T]]
-[[Category: Claudin c-terminus]]
-[[Category: Pdz domain]]
-[[Category: Peptide binding protein]]