3jv3: Difference between revisions

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{{STRUCTURE_3jv3|  PDB=3jv3  |  SCENE=  }}
===Structure of SH3E-DH unit of murine intersectin-1L===
{{ABSTRACT_PUBMED_20585582}}


==Function==
==Structure of SH3E-DH unit of murine intersectin-1L==
[[http://www.uniprot.org/uniprot/ITSN1_MOUSE ITSN1_MOUSE]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1.  
<StructureSection load='3jv3' size='340' side='right'caption='[[3jv3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JV3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jv3 OCA], [https://pdbe.org/3jv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jv3 RCSB], [https://www.ebi.ac.uk/pdbsum/3jv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jv3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITSN1_MOUSE ITSN1_MOUSE] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/3jv3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jv3 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3jv3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV3 OCA].
*[[Intersectin|Intersectin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020585582</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Ahmad, K F.]]
[[Category: Ahmad KF]]
[[Category: Autoinhibition]]
[[Category: Cell junction]]
[[Category: Cell projection]]
[[Category: Dh domain]]
[[Category: Domain-swapped]]
[[Category: Endocytosis]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Protein binding]]
[[Category: Sh3 domain]]
[[Category: Synapse]]
[[Category: Synaptosome]]
Retrieved from "https://proteopedia.org/3jv3"