3iwl: Difference between revisions

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{{STRUCTURE_3iwl|  PDB=3iwl  |  SCENE=  }}
===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===
{{ABSTRACT_PUBMED_19807176}}


==Function==
==Crystal structure of cisplatin bound to a human copper chaperone (monomer)==
[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
<StructureSection load='3iwl' size='340' side='right'caption='[[3iwl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWL FirstGlance]. <br>
[[3iwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [https://pdbe.org/3iwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [https://www.ebi.ac.uk/pdbsum/3iwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwl ProSAT]</span></td></tr>
<ref group="xtra">PMID:019807176</ref><references group="xtra"/><references/>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwl ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boal, A K.]]
[[Category: Large Structures]]
[[Category: Rosenzweig, A C.]]
[[Category: Boal AK]]
[[Category: Beta-alpha-beta-beta-alpha-beta]]
[[Category: Rosenzweig AC]]
[[Category: Chaperone]]
[[Category: Cisplatin]]
[[Category: Copper transport]]
[[Category: Ion transport]]
[[Category: Metal transport]]
[[Category: Metal-binding]]
[[Category: Platinum]]
[[Category: Transport]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3iwl"