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{{STRUCTURE_3jqh|  PDB=3jqh  |  SCENE=  }}
===Structure of the neck region of the glycan-binding receptor DC-SIGNR===
{{ABSTRACT_PUBMED_19835887}}


==Function==
==Structure of the neck region of the glycan-binding receptor DC-SIGNR==
[[http://www.uniprot.org/uniprot/CLC4M_HUMAN CLC4M_HUMAN]] Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.<ref>PMID:11257134</ref><ref>PMID:11226297</ref>  
<StructureSection load='3jqh' size='340' side='right'caption='[[3jqh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3jqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JQH FirstGlance]. <br>
[[3jqh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQH OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqh OCA], [https://pdbe.org/3jqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jqh RCSB], [https://www.ebi.ac.uk/pdbsum/3jqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqh ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:019835887</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/CLC4M_HUMAN CLC4M_HUMAN] Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.<ref>PMID:11257134</ref> <ref>PMID:11226297</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jqh ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Drickamer, K.]]
[[Category: Large Structures]]
[[Category: Feinberg, H.]]
[[Category: Drickamer K]]
[[Category: Taylor, M E.]]
[[Category: Feinberg H]]
[[Category: Tso, C K.W.]]
[[Category: Taylor ME]]
[[Category: Weis, W I.]]
[[Category: Tso CKW]]
[[Category: Cell membrane]]
[[Category: Weis WI]]
[[Category: Dc-signr]]
[[Category: Disulfide bond]]
[[Category: Endocytosis]]
[[Category: Four-helix bundle]]
[[Category: Glycoprotein]]
[[Category: Host-virus interaction]]
[[Category: Immune response]]
[[Category: Lectin]]
[[Category: Mannose-binding]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Oligomerization domain]]
[[Category: Receptor]]
[[Category: Secreted]]
[[Category: Signal-anchor]]
[[Category: Sugar binding protein]]
[[Category: Transmembrane]]
Retrieved from "https://proteopedia.org/3jqh"