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{{STRUCTURE_3ipi|  PDB=3ipi  |  SCENE=  }}
===Crystal Structure of a Geranyltranstransferase from the Methanosarcina mazei===


==Function==
==Crystal Structure of a Geranyltranstransferase from the Methanosarcina mazei==
[[http://www.uniprot.org/uniprot/Q8PYS1_METMA Q8PYS1_METMA]] Involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylfarnesyl diphosphate (GFPP). It prefers geranylgeranyl diphosphate (GGPP) and farnesyl diphosphate (FPP) as allylic substrate.  
<StructureSection load='3ipi' size='340' side='right'caption='[[3ipi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPI FirstGlance]. <br>
[[3ipi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei Methanosarcina mazei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPI OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
[[Category: Methanosarcina mazei]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
[[Category: Brown, A.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipi OCA], [https://pdbe.org/3ipi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipi RCSB], [https://www.ebi.ac.uk/pdbsum/3ipi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipi ProSAT]</span></td></tr>
[[Category: Burley, S K.]]
</table>
[[Category: Kumaran, D.]]
== Evolutionary Conservation ==
[[Category: Mohammed, M B.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
Check<jmol>
[[Category: Swaminathan, S.]]
  <jmolCheckbox>
[[Category: 11257e]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipi_consurf.spt"</scriptWhenChecked>
[[Category: Geranyltranstransferase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Helical bundle]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Isoprene biosynthesis]]
  </jmolCheckbox>
[[Category: New york sgx research center for structural genomic]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ipi ConSurf].
[[Category: Nysgxrc]]
<div style="clear:both"></div>
[[Category: Structural genomic]]
__TOC__
[[Category: Transferase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Brown A]]
[[Category: Burley SK]]
[[Category: Kumaran D]]
[[Category: Mohammed MB]]
[[Category: Swaminathan S]]
Retrieved from "https://proteopedia.org/3ipi"