3iv1: Difference between revisions
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== | ==Coiled-coil domain of tumor susceptibility gene 101== | ||
[[http://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN | <StructureSection load='3iv1' size='340' side='right'caption='[[3iv1]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3iv1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IV1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iv1 OCA], [https://pdbe.org/3iv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iv1 RCSB], [https://www.ebi.ac.uk/pdbsum/3iv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iv1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3iv1_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iv1 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
[[ | *[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Avvakumov | [[Category: Arrowsmith CH]] | ||
[[Category: Bochkarev | [[Category: Avvakumov GV]] | ||
[[Category: Bountra | [[Category: Bochkarev A]] | ||
[[Category: Dhe-Paganon | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Dhe-Paganon S]] | ||
[[Category: Li | [[Category: Edwards AM]] | ||
[[Category: Neculai | [[Category: Li Y]] | ||
[[Category: Neculai D]] | |||
[[Category: Walker | [[Category: Walker JR]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wernimont | [[Category: Wernimont AK]] | ||
[[Category: Xue | [[Category: Xue S]] | ||
Latest revision as of 05:54, 17 October 2024
Coiled-coil domain of tumor susceptibility gene 101
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