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{{STRUCTURE_3jra|  PDB=3jra  |  SCENE=  }}
===Crystal structure of Fis bound to 27bp non consensus sequence DNA F6===
{{ABSTRACT_PUBMED_20395367}}


==Function==
==Crystal structure of Fis bound to 27bp non consensus sequence DNA F6==
[[http://www.uniprot.org/uniprot/FIS_ECOLI FIS_ECOLI]] Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.<ref>PMID:2209559</ref><ref>PMID:8836178</ref>  
<StructureSection load='3jra' size='340' side='right'caption='[[3jra]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jra]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JRA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jra OCA], [https://pdbe.org/3jra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jra RCSB], [https://www.ebi.ac.uk/pdbsum/3jra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jra ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIS_ECOLI FIS_ECOLI] Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.<ref>PMID:2209559</ref> <ref>PMID:8836178</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/3jra_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jra ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3jra]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRA OCA].
*[[FIS protein|FIS protein]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020395367</ref><references group="xtra"/><references/>
__TOC__
[[Category: Escherichia coli]]
</StructureSection>
[[Category: Cascio, D.]]
[[Category: Escherichia coli K-12]]
[[Category: Johnson, R C.]]
[[Category: Large Structures]]
[[Category: Stella, S.]]
[[Category: Cascio D]]
[[Category: Activator]]
[[Category: Johnson RC]]
[[Category: Dna bending]]
[[Category: Stella S]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna-binding]]
[[Category: Hth domain]]
[[Category: Indirect recognition]]
[[Category: Minor groove compression]]
[[Category: Protein-dna complex]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
Retrieved from "https://proteopedia.org/3jra"