2dnp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2dnp.jpg|left|200px]]<br /><applet load="2dnp" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2dnp" />
'''Solution structure of RNA binding domain 2 in RNA-binding protein 14'''<br />


==Disease==
==Solution structure of RNA binding domain 2 in RNA-binding protein 14==
Known disease associated with this structure: Mowat-Wilson syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605802 605802]]
<StructureSection load='2dnp' size='340' side='right'caption='[[2dnp]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2dnp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNP FirstGlance]. <br>
2DNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNP OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnp OCA], [https://pdbe.org/2dnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnp RCSB], [https://www.ebi.ac.uk/pdbsum/2dnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnp ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnp TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBM14_HUMAN RBM14_HUMAN] Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/2dnp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dnp ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Kusuhara, M.]]
[[Category: Kusuhara M]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Tsuda K]]
[[Category: Tsuda, K.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: rbd]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rrm domain]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:00:51 2008''
Retrieved from "https://proteopedia.org/2dnp"