CD47: Difference between revisions

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<StructureSection load='' size='350' side='right' scene='53/538855/Cv/1' caption='Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions [[2jjs]]'>
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== Function ==


[[Image:2jjs.png|left|200px|thumb|Crystal structure of hCD47 residues 19-136 (mutant) complex with SIRP α [[2jjs]]]]
'''CD47 (Cluster of Differentiation 47)''' is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. <ref>PMID:22310103</ref>
{{STRUCTURE_2jjs| PDB=2jjs | SIZE=400| SCENE= |right|CAPTION=hCD47 residues 19-136 (mutant) Pink and yellow) complex with SIRP α (grey and green) [[2jjs]] }}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


== Relevance ==


Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested.  CD47 is an antigen on a variety of human cancer cells.


== Structural insights ==


'''CD47 (Cluster of Differentiation 47)''' is a protein which is expressed by cancer cells to avoid detection by the immune system.  Antobodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested.
CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain.
*<scene name='53/538855/Cv/3'>CD47 with SIRP α (cyan) and I-ions</scene> ([[2jjs]]).<ref>PMID:18657508</ref>
</StructureSection>


== 3D Structures of CD47 ==
== 3D Structures of CD47 ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[2jjs]], [[2jjt]] – hCD47 residues 19-136 (mutant) + SIRP α  <br />
[[7ygg]] – hCD47 extracellular domain 19-141 + SIRP α  - human<br />
[[2vsc]] – hCD47 residues 19-136 (mutant)  <br />
[[2jjs]], [[2jjt]], [[4kjy]] – hCD47 extracellular domain (mutant) + SIRP α  <br />
[[2vsc]] – hCD47 extracellular domain (mutant)  <br />
[[4cmm]] - hCD47 extracellular domain (mutant)  + tyrosine-protein phosphatase non-receptor type substrate<br />
[[5iwl]] – hCD47 extracellular domain (mutant) + 5F9 diabody  <br />
[[7wn8]] – hCD47 + antibody  <br />
[[7xjf]], [[8rp8]] – hCD47 extracellular domain + antibody  <br />
[[5tz2]], [[5tzt]], [[5tzu]] – hCD47 extracellular domain (mutant) + antibody <br />
[[7myz]] – hCD47 extracellular domain/cytochrome b562 + antibody  <br />
== References ==
<references/>
[[Category:Topic Page]]
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