4b6c: Difference between revisions

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{{STRUCTURE_4b6c|  PDB=4b6c  |  SCENE=  }}
===Structure of the M. smegmatis GyrB ATPase domain in complex with an aminopyrazinamide===
{{ABSTRACT_PUBMED_23268609}}


==Function==
==Structure of the M. smegmatis GyrB ATPase domain in complex with an aminopyrazinamide==
[[http://www.uniprot.org/uniprot/GYRB_MYCSM GYRB_MYCSM]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.  
<StructureSection load='4b6c' size='340' side='right'caption='[[4b6c]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4b6c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B6C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B5U:6-(3,4-DIMETHYLPHENYL)-3-[[4-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]PHENYL]AMINO]PYRAZINE-2-CARBOXAMIDE'>B5U</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b6c OCA], [https://pdbe.org/4b6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b6c RCSB], [https://www.ebi.ac.uk/pdbsum/4b6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b6c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GYRB_MYCSM GYRB_MYCSM] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.


==About this Structure==
==See Also==
[[4b6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6C OCA].
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
[[Category: Mycobacterium smegmatis]]
__TOC__
[[Category: Basu, R.]]
</StructureSection>
[[Category: Ghorpade, S.]]
[[Category: Large Structures]]
[[Category: Hussein, S.]]
[[Category: Mycolicibacterium smegmatis]]
[[Category: Madhavapeddi, P.]]
[[Category: Basu R]]
[[Category: Shirude, P S.]]
[[Category: Ghorpade S]]
[[Category: Tucker, J A.]]
[[Category: Hussein S]]
[[Category: Dna topoisomerase]]
[[Category: Madhavapeddi P]]
[[Category: Inhibitor]]
[[Category: Shirude PS]]
[[Category: Isomerase]]
[[Category: Tucker JA]]
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