4js8: Difference between revisions
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New page: '''Unreleased structure''' The entry 4js8 is ON HOLD Authors: Qiu, W., Plotnikov, A.N., Plotnikova, O., Feher, M., Awrey, D.E., Chirgadze, N.Y. Description: Crystal structure of TTK ki... |
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==Crystal structure of TTK kinase domain with an inhibitor: 401348== | |||
<StructureSection load='4js8' size='340' side='right'caption='[[4js8]], [[Resolution|resolution]] 1.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4js8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PF:4-(CYCLOHEXYLMETHOXY)-3-{4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-2H-INDAZOLE'>1PF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js8 OCA], [https://pdbe.org/4js8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js8 RCSB], [https://www.ebi.ac.uk/pdbsum/4js8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | |||
==See Also== | |||
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Awrey DE]] | |||
[[Category: Chirgadze NY]] | |||
[[Category: Feher M]] | |||
[[Category: Plotnikov AN]] | |||
[[Category: Plotnikova O]] | |||
[[Category: Qiu W]] | |||
Latest revision as of 11:01, 6 November 2024
Crystal structure of TTK kinase domain with an inhibitor: 401348
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