2dul: Difference between revisions

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[[Image:2dul.jpg|left|200px]]<br /><applet load="2dul" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2dul, resolution 1.90&Aring;" />
'''Crystal structure of tRNA G26 methyltransferase Trm1 in apo form from Pyrococcus horikoshii'''<br />


==About this Structure==
==Crystal structure of tRNA G26 methyltransferase Trm1 in apo form from Pyrococcus horikoshii==
2DUL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/tRNA_(guanine-N(2)-)-methyltransferase tRNA (guanine-N(2)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.32 2.1.1.32] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUL OCA].  
<StructureSection load='2dul' size='340' side='right'caption='[[2dul]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DUL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dul OCA], [https://pdbe.org/2dul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dul RCSB], [https://www.ebi.ac.uk/pdbsum/2dul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dul ProSAT], [https://www.topsan.org/Proteins/RSGI/2dul TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRM1_PYRHO TRM1_PYRHO] Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/2dul_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dul ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Single protein]]
[[Category: Bessho Y]]
[[Category: tRNA (guanine-N(2)-)-methyltransferase]]
[[Category: Bessho, Y.]]
[[Category: Ihsanawati]]
[[Category: Ihsanawati]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: GOL]]
[[Category: guanine 26]]
[[Category: n(2)]]
[[Category: n(2)-dimethyltransferase]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: trna modification enzyme]]
 
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Retrieved from "https://proteopedia.org/2dul"