4f46: Difference between revisions

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{{STRUCTURE_4f46|  PDB=4f46  |  SCENE=  }}
===Crystal structure of wild type human CD38 in complex with NAADP and ADPRP===


==Function==
==Crystal structure of wild type human CD38 in complex with NAADP and ADPRP==
[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.  
<StructureSection load='4f46' size='340' side='right'caption='[[4f46]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4f46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F46 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DN4:[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>DN4</scene>, <scene name='pdbligand=DVN:[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3S,4R,5S)-3,4,5-TRIS(OXIDANYL)OXOLAN-2-YL]METHYL+HYDROGEN+PHOSPHATE'>DVN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f46 OCA], [https://pdbe.org/4f46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f46 RCSB], [https://www.ebi.ac.uk/pdbsum/4f46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f46 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.


==About this Structure==
==See Also==
[[4f46]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F46 OCA].
*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hao, Q.]]
[[Category: Large Structures]]
[[Category: Lee, H C.]]
[[Category: Hao Q]]
[[Category: Zhang, H.]]
[[Category: Lee HC]]
[[Category: Adp-ribosyl cyclase]]
[[Category: Zhang H]]
[[Category: Calcium signaling]]
[[Category: Cd38]]
[[Category: Hydrolase]]
[[Category: Naadp]]
Retrieved from "https://proteopedia.org/4f46"