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{{STRUCTURE_3km5|  PDB=3km5  |  SCENE=  }}
===Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)===
{{ABSTRACT_PUBMED_20233299}}


==Function==
==Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)==
[[http://www.uniprot.org/uniprot/O52050_PORGI O52050_PORGI]] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]  
<StructureSection load='3km5' size='340' side='right'caption='[[3km5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3km5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_W83 Porphyromonas gingivalis W83]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KM5 FirstGlance]. <br>
[[3km5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM5 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3km5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3km5 OCA], [https://pdbe.org/3km5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3km5 RCSB], [https://www.ebi.ac.uk/pdbsum/3km5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3km5 ProSAT]</span></td></tr>
<ref group="xtra">PMID:020233299</ref><references group="xtra"/><references/>
</table>
[[Category: Porphyromonas gingivalis]]
== Function ==
[[Category: Collyer, C A.]]
[https://www.uniprot.org/uniprot/HAGA1_PORGI HAGA1_PORGI] Agglutinates erythrocytes.
[[Category: Hunter, N.]]
== Evolutionary Conservation ==
[[Category: Li, N.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Beta jelly roll barrel]]
Check<jmol>
[[Category: Cell invasion]]
  <jmolCheckbox>
[[Category: Cleaved adhesin family]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/3km5_consurf.spt"</scriptWhenChecked>
[[Category: Hemagglutination domain]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Lys-gingipain]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3km5 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porphyromonas gingivalis W83]]
[[Category: Collyer CA]]
[[Category: Hunter N]]
[[Category: Li N]]

Latest revision as of 08:29, 20 March 2024

Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)

3km5, resolution 1.40Å

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