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{{STRUCTURE_3ko0|  PDB=3ko0  |  SCENE=  }}
===Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor===
{{ABSTRACT_PUBMED_20421509}}


==About this Structure==
==Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor==
[[3ko0]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO0 OCA].  
<StructureSection load='3ko0' size='340' side='right'caption='[[3ko0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ko0]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KO0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TFP:10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE'>TFP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ko0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ko0 OCA], [https://pdbe.org/3ko0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ko0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ko0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ko0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S10A4_HUMAN S10A4_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3ko0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ko0 ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
<ref group="xtra">PMID:020421509</ref><references group="xtra"/><references/>
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Large Structures]]
[[Category: Bresnick, A R.]]
[[Category: Almo SC]]
[[Category: Dulyaninova, N G.]]
[[Category: Bresnick AR]]
[[Category: Knight, D.]]
[[Category: Dulyaninova NG]]
[[Category: Malashkevich, V N.]]
[[Category: Knight D]]
[[Category: Ca2+]]
[[Category: Malashkevich VN]]
[[Category: Metal binding protein]]
[[Category: Mts1]]
[[Category: Oligomerization]]
[[Category: S100a4]]
[[Category: Tfp]]
Retrieved from "https://proteopedia.org/3ko0"