3ki2: Difference between revisions
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== | ==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G== | ||
[[http://www.uniprot.org/uniprot/ | <StructureSection load='3ki2' size='340' side='right'caption='[[3ki2]], [[Resolution|resolution]] 1.28Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [https://pdbe.org/3ki2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | |||
== | ==See Also== | ||
[[ | *[[Exotoxin 3D structures|Exotoxin 3D structures]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
[[Category: Edwards | [[Category: Edwards PR]] | ||
[[Category: Jorgensen | [[Category: Jorgensen R]] | ||
[[Category: Merrill | [[Category: Merrill AR]] | ||
Latest revision as of 08:16, 6 September 2023
Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G
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