3km8: Difference between revisions
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== | ==Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine== | ||
[[http://www.uniprot.org/uniprot/ADA_MOUSE ADA_MOUSE | <StructureSection load='3km8' size='340' side='right'caption='[[3km8]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3km8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KM8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DI:9-DEAZAINOSINE'>9DI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3km8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3km8 OCA], [https://pdbe.org/3km8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3km8 RCSB], [https://www.ebi.ac.uk/pdbsum/3km8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3km8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ADA_MOUSE ADA_MOUSE] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). | |||
== | ==See Also== | ||
[[ | *[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]] | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Fan | [[Category: Fan X]] | ||
[[Category: Gao | [[Category: Gao Y]] | ||
Latest revision as of 10:41, 16 August 2023
Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine
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