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{{STRUCTURE_3ki5|  PDB=3ki5  |  SCENE=  }}
===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-M===


==Function==
==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-M==
[[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
<StructureSection load='3ki5' size='340' side='right'caption='[[3ki5]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ki5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9M:N-(6-OXO-5,6-DIHYDROBENZO[C][1,5]NAPHTHYRIDIN-2-YL)-2-(4-PYRROLIDIN-1-YLPIPERIDIN-1-YL)ACETAMIDE'>G9M</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki5 OCA], [https://pdbe.org/3ki5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>  


==About this Structure==
==See Also==
[[3ki5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI5 OCA].
*[[Exotoxin 3D structures|Exotoxin 3D structures]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
[[Category: Edwards, P R.]]
[[Category: Edwards PR]]
[[Category: Jorgensen, R.]]
[[Category: Jorgensen R]]
[[Category: Merrill, A R.]]
[[Category: Merrill AR]]
[[Category: Adp-ribosyl transferase]]
[[Category: Alpha-beta complex]]
[[Category: Diphthamide]]
[[Category: Toxin]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3ki5"