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| {{STRUCTURE_3kwu| PDB=3kwu | SCENE= }}
| | #REDIRECT [[6nyt]] This PDB entry is obsolete and replaced by 6nyt |
| ===Munc13-1 C2B-domain, calcium bound===
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| {{ABSTRACT_PUBMED_20154707}}
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| ==Function==
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| [[http://www.uniprot.org/uniprot/UN13A_RAT UN13A_RAT]] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion.<ref>PMID:9697857</ref> <ref>PMID:11343654</ref> <ref>PMID:11792326</ref> | |
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| ==About this Structure==
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| [[3kwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWU OCA].
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| ==Reference==
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| <ref group="xtra">PMID:020154707</ref><references group="xtra"/><references/>
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| [[Category: Rattus norvegicus]]
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| [[Category: Lu, J.]]
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| [[Category: Machius, M.]]
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| [[Category: Rizo, J.]]
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| [[Category: Tomchick, D R.]]
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| [[Category: Calcium binding protein]]
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| [[Category: Metal binding protein]]
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| [[Category: Phospholipid binding protein]]
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