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{{STRUCTURE_3kvv|  PDB=3kvv  |  SCENE=  }}
===Trapping of an oxocarbenium ion intermediate in UP crystals===
{{ABSTRACT_PUBMED_20364833}}


==Function==
==Trapping of an oxocarbenium ion intermediate in UP crystals==
[[http://www.uniprot.org/uniprot/UDP_ECOLI UDP_ECOLI]] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.  
<StructureSection load='3kvv' size='340' side='right'caption='[[3kvv]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3kvv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KVV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R2B:1,4-ANHYDRO-D-ERYTHRO-PENT-1-ENITOL'>R2B</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvv OCA], [https://pdbe.org/3kvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kvv RCSB], [https://www.ebi.ac.uk/pdbsum/3kvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UDP_ECOLI UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/3kvv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kvv ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3kvv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVV OCA].
*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020364833</ref><references group="xtra"/><references/>
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Uridine phosphorylase]]
[[Category: Begley TP]]
[[Category: Begley, T P.]]
[[Category: Bu W]]
[[Category: Bu, W.]]
[[Category: Ealick SE]]
[[Category: Ealick, S E.]]
[[Category: O'Leary S]]
[[Category: Leary, S O.]]
[[Category: Paul D]]
[[Category: Paul, D.]]
[[Category: Rajashankar K]]
[[Category: Rajashankar, K.]]
[[Category: Sanders J]]
[[Category: Sanders, J.]]
[[Category: Settembre E]]
[[Category: Settembre, E.]]
[[Category: Toms A]]
[[Category: Toms, A.]]
[[Category: Glycal]]
[[Category: Glycosyltransferase]]
[[Category: Oxocarbenium ion]]
[[Category: Pyrimidine salvage]]
[[Category: Transferase]]
[[Category: Uridine phosphorylase]]
Retrieved from "https://proteopedia.org/3kvv"