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{{STRUCTURE_3kzd|  PDB=3kzd  |  SCENE=  }}
===Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain===
{{ABSTRACT_PUBMED_20361982}}


==Function==
==Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain==
[[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.  
<StructureSection load='3kzd' size='340' side='right'caption='[[3kzd]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3kzd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZD FirstGlance]. <br>
[[3kzd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZD OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzd OCA], [https://pdbe.org/3kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kzd RCSB], [https://www.ebi.ac.uk/pdbsum/3kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kzd ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:020361982</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kzd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kzd ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fuentes, E J.]]
[[Category: Large Structures]]
[[Category: Shepherd, T R.]]
[[Category: Fuentes EJ]]
[[Category: Cell adhesion]]
[[Category: Shepherd TR]]
[[Category: Cell junction]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Lipoprotein]]
[[Category: Myristate]]
[[Category: Pdz]]
[[Category: Phosphoprotein]]
[[Category: Signaling protein]]
[[Category: Tiam1]]
Retrieved from "https://proteopedia.org/3kzd"