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New page: left|200px<br /><applet load="2ec7" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ec7" /> '''Solution Structure of Human Immunodificiency...
 
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[[Image:2ec7.jpg|left|200px]]<br /><applet load="2ec7" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2ec7" />
'''Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein'''<br />


==About this Structure==
==Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein==
2EC7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+50'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+51'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC7 OCA].
<StructureSection load='2ec7' size='340' side='right'caption='[[2ec7]]' scene=''>
[[Category: Human immunodeficiency virus 1]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2ec7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(ISOLATE_GHANA-1) Human immunodeficiency virus type 2 (ISOLATE GHANA-1)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC7 FirstGlance]. <br>
[[Category: Endoh, H.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
[[Category: Kodera, Y.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Kohno, T.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec7 OCA], [https://pdbe.org/2ec7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec7 ProSAT]</span></td></tr>
[[Category: Komatsu, H.]]
</table>
[[Category: Maeda, T.]]
== Function ==
[[Category: Matsui, T.]]
[https://www.uniprot.org/uniprot/GAG_HV2G1 GAG_HV2G1] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity).  Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).  p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
[[Category: Miyauchi, E.]]
== Evolutionary Conservation ==
[[Category: Tanaka, H.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Tanaka, T.]]
Check<jmol>
[[Category: ZN]]
  <jmolCheckbox>
[[Category: hiv-2]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec7_consurf.spt"</scriptWhenChecked>
[[Category: nucleocapsid protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: rna recognition]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: viral protein]]
  </jmolCheckbox>
[[Category: zinc finger]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ec7 ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:08:31 2008''
==See Also==
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Endoh H]]
[[Category: Kodera Y]]
[[Category: Kohno T]]
[[Category: Komatsu H]]
[[Category: Maeda T]]
[[Category: Matsui T]]
[[Category: Miyauchi E]]
[[Category: Tanaka H]]
[[Category: Tanaka T]]
Retrieved from "https://proteopedia.org/2ec7"