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{{STRUCTURE_3mca|  PDB=3mca  |  SCENE=  }}
===Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay===
{{ABSTRACT_PUBMED_20890290}}


==Function==
==Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay==
[[http://www.uniprot.org/uniprot/HBS1_SCHPO HBS1_SCHPO]] Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs (By similarity).[UniProtKB:P32769] [[http://www.uniprot.org/uniprot/DOM34_SCHPO DOM34_SCHPO]] Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions (By similarity).[UniProtKB:P33309]  
<StructureSection load='3mca' size='340' side='right'caption='[[3mca]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3mca]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MCA FirstGlance]. <br>
[[3mca]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCA OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mca OCA], [https://pdbe.org/3mca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mca RCSB], [https://www.ebi.ac.uk/pdbsum/3mca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mca ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:020890290</ref><references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/HBS1_SCHPO HBS1_SCHPO] Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs (By similarity).[UniProtKB:P32769]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/3mca_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mca ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Chen, L.]]
[[Category: Chen L]]
[[Category: Song, H.]]
[[Category: Song H]]
[[Category: No-go decay]]
[[Category: Protein protein complex]]
[[Category: Translation regulation]]
[[Category: Translation regulation-hydrolase complex]]
Retrieved from "https://proteopedia.org/3mca"