2egs: Difference between revisions
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== | ==Crystal structure of Leu261 to Met mutant of Diphthine synthase== | ||
<StructureSection load='2egs' size='340' side='right'caption='[[2egs]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
[ | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2egs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EGS FirstGlance]. <br> | |||
[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2egs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2egs OCA], [https://pdbe.org/2egs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2egs RCSB], [https://www.ebi.ac.uk/pdbsum/2egs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2egs ProSAT], [https://www.topsan.org/Proteins/RSGI/2egs TOPSAN]</span></td></tr> | |||
</table> | |||
[ | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref> | ||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
[[ | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/2egs_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
[ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2egs ConSurf]. | ||
[[ | <div style="clear:both"></div> | ||
[ | |||
==See Also== | |||
*[[Diphthine synthase|Diphthine synthase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pyrococcus horikoshii OT3]] | |||
[[Category: Krishna Swamy BS]] | |||
[[Category: Kunishima N]] | |||
[[Category: Matsuura Y]] | |||
[[Category: Mizutani H]] | |||
[[Category: Murthy MRN]] | |||
[[Category: Simanshu DK]] | |||
Latest revision as of 05:55, 6 August 2025
Crystal structure of Leu261 to Met mutant of Diphthine synthase
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