3m6a: Difference between revisions

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{{STRUCTURE_3m6a|  PDB=3m6a  |  SCENE=  }}
===Crystal structure of Bacillus subtilis Lon C-terminal domain===
{{ABSTRACT_PUBMED_20600124}}


==Function==
==Crystal structure of Bacillus subtilis Lon C-terminal domain==
[[http://www.uniprot.org/uniprot/LON1_BACSU LON1_BACSU]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973]  
<StructureSection load='3m6a' size='340' side='right'caption='[[3m6a]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3m6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M6A FirstGlance]. <br>
[[3m6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6A OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m6a OCA], [https://pdbe.org/3m6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m6a RCSB], [https://www.ebi.ac.uk/pdbsum/3m6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m6a ProSAT]</span></td></tr>
<ref group="xtra">PMID:020600124</ref><references group="xtra"/><references/>
</table>
[[Category: Bacillus subtilis]]
== Function ==
[[Category: Endopeptidase La]]
[https://www.uniprot.org/uniprot/LON1_BACSU LON1_BACSU] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973]
[[Category: Duman, R E.]]
== Evolutionary Conservation ==
[[Category: Lowe, J Y.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Alpha]]
Check<jmol>
[[Category: Atp-binding]]
  <jmolCheckbox>
[[Category: Beta]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/3m6a_consurf.spt"</scriptWhenChecked>
[[Category: Hydrolase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Nucleotide-binding]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Protease]]
  </jmolCheckbox>
[[Category: Serine protease]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m6a ConSurf].
[[Category: Stress response]]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Large Structures]]
[[Category: Duman RE]]
[[Category: Lowe JY]]
Retrieved from "https://proteopedia.org/3m6a"