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| [[Image:1eeq.png|left|200px|thumb|Crystal structure of SSB complex with ssDNA [[1eeq]]]]
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| {{STRUCTURE_1eeq| PDB=1eeq | SIZE=350| SCENE= |right|CAPTION=SSB complex with ssDNA [[1eeq]] }}
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| | <StructureSection load='1eqq' size='350' side='right' scene='' caption='E. coli SSB complex with ssDNA (stick model) and UMP [[1eqq]]'> |
| | '''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities<ref>PMID:22976174</ref>.<br /> |
| | * '''Viral SSB proteins''' are monomeric.<br /> |
| | * '''Eukaryotic SSB''' ('''Replication protein A''' – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD).<br /> |
| | *'''Replication protein A70''' is the eukaryotic SSB 70kDa subunit<ref>PMID:11470540</ref>. |
| | * '''Mitochondrial human SSB (HsmtSSB)''' is a homotetramer. |
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| | | See also [[Single stranded binding protein]]. |
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| '''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities.
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| == 3D Structures of single-stranded DNA-binding protein == | | == 3D Structures of single-stranded DNA-binding protein == |
| | [[Single-stranded DNA-binding protein 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| [[1gpc]] – SSB gp32 – Enterobacteria phage T4 <br />
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| [[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br />
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| [[1je5]] – SSB – Enterobacteria phage T7 <br />
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| [[1adu]], [[1adv]], [[1anv]] – SSB C terminal – human adenovirus 5 <br />
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| [[1urj]] – SSB – human herpesvirus 1 <br />
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| [[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br />
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| [[3ull]], [[1s3o]], [[2dud]] – SSB – human <br />
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| [[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br />
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| [[1qvc]], [[1sru]] – EcSSB <br />
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| [[1o7i]] – SSB residues 1-119 – ''Sulfolobus solfataricus''<br />
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| [[1ue1]], [[1ue5]], [[1ue7]] – SSB – ''Mycobacterium tuberculosis'' <br />
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| [[1x3e]], [[1x3f]], [[1x3g]] – MsSSB – ''Mycobacterium smegmatis'' <br />
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| [[1se8]] – DrSSB – ''Deinococcus radiodurans'' <br />
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| [[4exw]] – SSB DdrB – ''Deinococcus geothermalis'' <br />
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| [[1z9f]] – SSB – ''Thermotoga maritima'' <br />
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| [[2cwa]] – SSB – ''Thermus thermophilus'' <br />
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| [[2fxq]], [[2ihe]] – TaSSB – ''Thermus aquaticus'' <br />
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| [[2ihf]] – TaSSB (mutant) <br />
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| [[2hql]] – SSB – ''Mycoplasma pneumoniae'' <br />
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| [[3eiv]] – ScSSB – ''Streptomyces coelicolor''<br />
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| [[4dam]] – ScSSB (mutant) <br />
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| [[3lgj]], [[3pgz]] – SSB – ''Bartonella henselae'' <br />
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| [[3afp]], [[3afq]] – SSB – ''Mycobacterium leprae'' <br />
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| [[3tqy]] – SSB – ''Coxiella burnetii'' <br />
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| [[3tek]] – SSB N terminal – ''Thermoproteus tenax''<br />
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| [[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br />
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| ===SSB complex with ssDNA===
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| [[1eyg]] – EcSSB chymotryptic domain + ssDNA <br />
| | == References == |
| [[1eqq]] – EcSSB + ssDNA <br />
| | <references/> |
| [[2vw9]] – HpSSB + ssDNA <br />
| | [[Category:Topic Page]] |
| [[3vdy]] – SSB + ssDNA – ''Bacillus subtilis''<br />
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| [[3a5u]] – MsSSB chymotryptic domain + ssDNA <br /> | |
| [[3udg]] – DrSSB + ssDNA <br />
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