4i0i: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4i0i is ~~ON HOLD until Paper Publication~~

==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors==

== Structural highlights ==

<table><tr><td colspan='2'>[[4i0i]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4I0I FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=957:N-[(1S,2R)-1-(3,5-DIFLUOROBENZYL)-3-({1-[4-(2,2-DIMETHYLPROPYL)THIOPHEN-2-YL]CYCLOPROPYL}AMINO)-2-HYDROXYPROPYL]ACETAMIDE'>957</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0i OCA], [https://pdbe.org/4i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0i RCSB], [https://www.ebi.ac.uk/pdbsum/4i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0i ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

~~Authors~~: ~~Yao, N.,~~ Brecht, E.

==See Also==

*[[Beta secretase 3D structures|Beta secretase 3D structures]]

~~Description~~: ~~SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors~~

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Brecht E]]

[[Category: Yao N]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4i0i is ON HOLD  until Paper Publication
+==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors==
+<StructureSection load='4i0i' size='340' side='right'caption='[[4i0i]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4i0i]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0I FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=957:N-[(1S,2R)-1-(3,5-DIFLUOROBENZYL)-3-({1-[4-(2,2-DIMETHYLPROPYL)THIOPHEN-2-YL]CYCLOPROPYL}AMINO)-2-HYDROXYPROPYL]ACETAMIDE'>957</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0i OCA], [https://pdbe.org/4i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0i RCSB], [https://www.ebi.ac.uk/pdbsum/4i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0i ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Yao, N., Brecht, E.
+==See Also==
+*[[Beta secretase 3D structures|Beta secretase 3D structures]]
-Description: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Brecht E]]
+[[Category: Yao N]]